Development of a series of bis-triazoles as G-quadruplex ligands-Reference-Cited by-同舟云学术

Development of a series of bis-triazoles as G-quadruplex ligands

Published:2017 Issue:75 Volume:7 Page:47297-47308
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Saleh Maysaa M.¹²³⁴⁵^ORCID,Laughton Charles A.¹²³⁴⁵^ORCID,Bradshaw Tracey D.¹²³⁴⁵^ORCID,Moody Christopher J.⁶³⁵⁷^ORCID

Affiliation:

1. School of Pharmacy

2. Centre of Bimolecular Science

3. University of Nottingham

4. University Park

5. Nottingham NG7 2RD

6. School of Chemistry

7. UK

Abstract

Maintenance of telomeres – specialized complexes that protect the ends of chromosomes – is provided by the enzyme complex telomerase, which is a key factor that is activated in more than 80% of cancer cells, but absent in most normal cells.

Funder

Islamic Development Bank

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA07257K

Reference40 articles.

1. Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands

2. Telomere Biology of Human Hematopoietic Stem Cells

3. A theory of marginotomy

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