Transition metal(<scp>ii</scp>) complexes of halogenated derivatives of (<i>E</i>)-4-(2-(pyridin-2-ylmethylene)hydrazinyl)quinazoline: structure, antioxidant activity, DNA-binding DNA photocleavage, interaction with albumin and <i>in silico</i> studies-Reference-Cited by-同舟云学术

Transition metal(ii) complexes of halogenated derivatives of (E)-4-(2-(pyridin-2-ylmethylene)hydrazinyl)quinazoline: structure, antioxidant activity, DNA-binding DNA photocleavage, interaction with albumin and in silico studies

Published:2022 Issue:43 Volume:51 Page:16688-16705
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Kakoulidou Chrisoula¹,Chasapis Christos T.²^ORCID,Hatzidimitriou Antonios G.¹,Fylaktakidou Konstantina C.³^ORCID,Psomas George¹^ORCID

Affiliation:

1. Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece

2. NMR Facility, Instrumental Analysis Laboratory, School of Natural Sciences, University of Patras, Greece

3. Laboratory of Organic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece

Abstract

Six transition metal(ii) complexes with halogenated quinazoline derivatives as ligands were characterized and evaluated for interaction with calf-thymus DNA, photocleavage of plasmid-DNA, affinity for bovine serum albumin, and antioxidant activity.

Funder

General Secretariat for Research and Technology

Hellenic Foundation for Research and Innovation

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/DT/D2DT02622H

Reference82 articles.

1. Quinazoline Based HDAC Dual Inhibitors as Potential Anti-Cancer Agents

2. Therapeutic progression of quinazolines as targeted chemotherapeutic agents