Heterocyclic (pyrazine)carboxamide Ru(<scp>ii</scp>) complexes: structural, experimental and theoretical studies of interactions with biomolecules and cytotoxicity-Reference-Cited by-同舟云学术

Heterocyclic (pyrazine)carboxamide Ru(ii) complexes: structural, experimental and theoretical studies of interactions with biomolecules and cytotoxicity

Published:2024 Issue:12 Volume:14 Page:8322-8330
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Tsaulwayo Nokwanda¹,Omondi Reinner O.¹^ORCID,Vijayan Paranthaman¹^ORCID,Sibuyi Nicole R. S.²^ORCID,Meyer Miché D.²,Meyer Mervin²,Ojwach Stephen O.¹^ORCID

Affiliation:

1. School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X01, Scottsville, Pietermaritzburg 3209, South Africa

2. Department of Science and Innovation/Mintek Nanotechnology Innovation Centre, Biolabels Research Node, Department of Biotechnology, University of the Western Cape, Bag X17, Bellville, 7535, Cape Town, South Africa

Abstract

The heterocyclic (pyrazine)carboxamide Ru(ii) complexes interact with CT-DNA through minor groove binding and partial intercalation modes and exhibit significant cytotoxicity and selectivity against A549, PC-3, and Caco-2 cell lines.

Funder

National Research Foundation

Nanotechnology Innovation Centre

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA00525B

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