Synthesis and biological evaluation of novel β-lactam-metallo β-lactamase inhibitors-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of novel β-lactam-metallo β-lactamase inhibitors

Published:2023 Issue:28 Volume:13 Page:18991-19001
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Shungube Mbongeni¹^ORCID,Hlophe Ayanda K.¹,Girdhari Letisha¹^ORCID,Sabe Victor T.¹,Peters Byron B.¹,Reddy Nakita¹^ORCID,Omolabi Kehinde F.¹,Chetty Lloyd¹,Arumugam Thilona²,Chuturgoon Anil²^ORCID,Kruger Hendrik G.¹^ORCID,Arvidsson Per I.¹³^ORCID,Qin Hua-Li⁴^ORCID,Naicker Tricia¹^ORCID,Govender Thavendran⁵

Affiliation:

1. Catalysis and Peptide Research Unit, University of KwaZulu Natal, Durban, 4001, South Africa

2. School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa

3. Science for Life Laboratory, Drug Discovery & Development Platform & Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

4. School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, 205 Luoshi Road, Wuhan, 430070, P. R. China

5. Department of Chemistry, University of Zululand, Private Bag X1001, KwaDlangezwa 3886, South Africa

Abstract

β-lactamases are enzymes that deactivate β-lactam antibiotics through a hydrolysis mechanism.

Funder

South African Agency for Science and Technology Advancement

National Research Foundation

South African Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA02490C

Reference42 articles.

1. B. C. N.Torres , Antibiotic Use and Resistance in South Africa: The Need for Better Data , available from: https://www.hsrc.ac.za/en/review/hsrc-review-june-2019/antibiotic-use-and-resistance-in-sa , [cited 2021 14 September 2021]

2. Tackling the threat of antimicrobial resistance: from policy to sustainable action

3. Metallo-β-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design

4. Antibiotic discovery: history, methods and perspectives

5. Enhanced antibiotic resistance as a collateral COVID-19 pandemic effect?

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