Indole-3-acetamide from gut microbiota activated hepatic AhR and mediated the remission effect of <i>Lactiplantibacillus plantarum</i> P101 on alcoholic liver injury in mice-Reference-Cited by-同舟云学术

Indole-3-acetamide from gut microbiota activated hepatic AhR and mediated the remission effect of Lactiplantibacillus plantarum P101 on alcoholic liver injury in mice

Published:2023 Issue:23 Volume:14 Page:10535-10548
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Wang Mengqi¹,Feng Xiaoyan¹,Zhao Yu¹,Lan Yuzhi¹,Xu Hengyi¹²^ORCID

Affiliation:

1. State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, P.R. China

2. International Institute of Food Innovation, Nanchang University, Nanchang 330299, P.R. China

Abstract

L. plantarum P101 alleviated alcoholic liver damage by regulating gut microbiota and its metabolites. The altered metabolite indole-3-acetamide activated the AhR signaling pathway and alleviated alcoholic injury in HepG2 cells.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D3FO03585A

Reference51 articles.

1. World Health Organization , Global status report on alcohol and health 2018 , World Health Organization , 2019

2. Pathogenesis of alcoholic liver disease: Role of oxidative metabolism

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4. Microbiota and Fatty Liver Disease—the Known, the Unknown, and the Future

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