Theoretical study of the hydrolysis mechanism of dihydrocoumarin catalyzed by serum paraoxonase 1 (PON1): different roles of Glu53 and His115 for catalysis-Reference-Cited by-同舟云学术

Theoretical study of the hydrolysis mechanism of dihydrocoumarin catalyzed by serum paraoxonase 1 (PON1): different roles of Glu53 and His115 for catalysis

Published:2016 Issue:65 Volume:6 Page:60376-60384
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Lin Beibei¹²³⁴,Su Hao¹²³⁴,Ma Guangcai¹²³⁴,Liu Yongjun¹²³⁴,Hou Qianqian⁵³⁴

Affiliation:

1. School of Chemistry and Chemical Engineering

2. Shandong University

3. Jinan

4. China

5. Shandong Non-metallic Materials Institute

Abstract

In the PON1-catalyzed hydrolysis of dihydrocoumarin, Glu53 is necessary whereas His115 is not essential but can promote the activity.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA09735A

Reference52 articles.

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