Similar Active Sites and Mechanisms Do Not Lead to Cross-Promiscuity in Organophosphate Hydrolysis: Implications for Biotherapeutic Engineering-Reference-Cited by-同舟云学术

Similar Active Sites and Mechanisms Do Not Lead to Cross-Promiscuity in Organophosphate Hydrolysis: Implications for Biotherapeutic Engineering

Published:2017-11-21 Issue:48 Volume:139 Page:17533-17546
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Purg Miha¹^ORCID,Elias Mikael²^ORCID,Kamerlin Shina Caroline Lynn¹^ORCID

Affiliation:

1. Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, BMC Box 596, S-751 24 Uppsala, Sweden

2. Department of Biochemistry, Molecular Biology and Biophysics & Biotechnology Institute, University of Minnesota, 1479 Gortner Avenue, St. Paul, Minnesota 55108, United States

Funder

Royal Swedish Academy of Sciences

Knut och Alice Wallenbergs Stiftelse

H2020 European Research Council

University of Minnesota BioTechnology Institute

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

http://pubs.acs.org/doi/pdf/10.1021/jacs.7b09384

Reference116 articles.

1. Inhibitory Potency against Human Acetylcholinesterase and Enzymatic Hydrolysis of Fluorogenic Nerve Agent Mimics by Human Paraoxonase 1 and Squid Diisopropyl Fluorophosphatase

2. Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

3. Organophosphate Pesticides: Biochemistry and Clinical Toxicology

4. Organophosphate Nerve Agents

5. Management of acute organophosphorus pesticide poisoning

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