Mechanical unfolding of ensemble biomolecular structures by shear force

Author:

Hu Changpeng1234,Jonchhe Sagun1234ORCID,Pokhrel Pravin1234,Karna Deepak1234ORCID,Mao Hanbin1234ORCID

Affiliation:

1. Department of Chemistry & Biochemistry and School of Biomedical Sciences

2. Advanced Materials and Liquid Crystal Institute

3. Kent State University Kent

4. USA

Abstract

Shear force in a homogenizer mechanically unfolds an ensemble set of biomolecular structures.

Funder

Division of Chemical, Bioengineering, Environmental, and Transport Systems

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Reference23 articles.

1. Nanomechanical measurements of the sequence-dependent folding landscapes of single nucleic acid hairpins

2. I. Vilfan , J.Lipfert , D.Koster , S.Lemay and N.Dekker , in Handbook of Single-Molecule Biophysics , ed. P. Hinterdorfer and A. Oijen , Springer US , 2009 , ch. 13, pp. 371–395

3. How Strong Is a Covalent Bond?

4. Behavior of Supercoiled DNA

5. Massively Parallel Single-Molecule Manipulation Using Centrifugal Force

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