Development of a near-infrared ratiometric fluorescent probe for glutathione using an intramolecular charge transfer signaling mechanism and its bioimaging application in living cells

Author:

Zhou Yong12345,Zhang Li12345,Zhang Xuan12345ORCID,Zhu Zhi-Jia12345

Affiliation:

1. Key Laboratory of Science and Technology of Eco-Textiles

2. Ministry of Education

3. College of Chemistry, Chemical Engineering and Biotechnology

4. Donghua University

5. Shanghai 201620

Abstract

A novel NIR ratiometric fluorescent probe HBT-GSH was developed for the selective detection of GSH over Cys and Hcy in aqueous solution. The signaling mechanism of the GSH-induced removal of an acetyl group and the switching on of ICT fluorescence was proposed.

Funder

Natural Science Foundation of Shanghai

Dalian University of Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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