Scalable synthesis of highly stable cyclopropene building blocks: application for bioorthogonal ligation with tetrazines-Reference-Cited by-同舟云学术

Scalable synthesis of highly stable cyclopropene building blocks: application for bioorthogonal ligation with tetrazines

Published:2023 Issue:17 Volume:10 Page:4223-4229
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Chen Lei¹,Yang Yuan²,Li Fei²,Jin Fei¹,He Bin¹^ORCID,Yang Jun²^ORCID

Affiliation:

1. State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Key Laboratory of Pharmaceutics, School of Pharmacy, Guizhou Medical University, Guiyang 550004, China

2. Key Laboratory of Macromolecular Science of Shaanxi Province, Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119, China

Abstract

We reported a new synthetic route to a stable and versatile cyclopropene precursor. It solves the issues of instability, low boiling points, and difficulties in scale-up processes.

Funder

Guizhou Science and Technology Department

Shaanxi Normal University

Guizhou Medical University

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO00816A

Reference27 articles.

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3. Live-Cell Imaging of Cyclopropene Tags with Fluorogenic Tetrazine Cycloadditions

4. Isomeric Cyclopropenes Exhibit Unique Bioorthogonal Reactivities

5. Rapid and Efficient Generation of Stable Antibody-Drug Conjugates via an Encoded Cyclopropene and an Inverse-Electron-Demand Diels-Alder Reaction

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