Rapid and Efficient Generation of Stable Antibody-Drug Conjugates via an Encoded Cyclopropene and an Inverse-Electron-Demand Diels-Alder Reaction-Reference-Cited by-同舟云学术

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Rapid and Efficient Generation of Stable Antibody-Drug Conjugates via an Encoded Cyclopropene and an Inverse-Electron-Demand Diels-Alder Reaction

Published:2018-02-14 Issue:11 Volume:57 Page:2831-2834
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Oller-Salvia Benjamí¹^ORCID,Kym Gene¹,Chin Jason W.¹^ORCID

Affiliation:

1. Medical Research Council Laboratory of Molecular Biology; Francis Crick Avenue Cambridge CB2 0QH UK

Funder

Medical Research Council

European Molecular Biology Organization

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/anie.201712370/fullpdf

Reference30 articles.

1. Strategies and challenges for the next generation of antibody–drug conjugates

2. Site-Specific Antibody–Drug Conjugates: The Nexus of Bioorthogonal Chemistry, Protein Engineering, and Drug Development

3. Expanding and reprogramming the genetic code

4. Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins

5. Antibody Conjugates with Unnatural Amino Acids

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