Asymmetric construction of densely functionalized three-dimensional aza-tetracyclic scaffolds for drug discovery-Reference-Cited by-同舟云学术

Asymmetric construction of densely functionalized three-dimensional aza-tetracyclic scaffolds for drug discovery

Published:2022 Issue:98 Volume:58 Page:13592-13595
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Umedera Kohei¹,Morita Taiki¹²,Nakamura Hiroyuki¹²^ORCID

Affiliation:

1. School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta-cho Midori-ku, Yokohama, 226-8503, Japan

2. Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-cho Midori-ku, Yokohama, 226-8503, Japan

Abstract

Asymmetric synthesis of 3D tetracyclic scaffold has been achieved. Three substituents (R1, R2, R3) were introduced in two different 3D patterns, providing opportunity to explore vast chemical space and thus discovery of novel bioactive compounds.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC05700J

Reference24 articles.

1. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

2. Escape from Flatland 2: complexity and promiscuity

3. Grand Challenge Commentary: Accessing new chemical space for 'undruggable' targets

4. Molecular Shape Diversity of Combinatorial Libraries: A Prerequisite for Broad Bioactivity

5. Expanding medicinal chemistry space

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