Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor-Reference-Cited by-同舟云学术

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Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor

Published:2016 Issue:3 Volume:7 Page:531-536
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Bach Anders¹²³⁴,Pedersen Thomas B.¹²³⁴,Strømgaard Kristian¹²³⁴

Affiliation:

1. Department of Drug Design and Pharmacology

2. University of Copenhagen

3. DK-2100 Copenhagen

4. Denmark

Abstract

A novel PSD-95 PDZ2 peptidomimetic has been discovered by designing azide and alkyne amino acid analogues and click chemistry.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C5MD00445D

Reference41 articles.

1. The Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View

2. PSD-95 Assembles a Ternary Complex with theN-Methyl-d-aspartic Acid Receptor and a Bivalent Neuronal NO Synthase PDZ Domain

3. Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions

4. A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

5. Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain

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1. Rational Design of PDZ Domain Inhibitors: Discovery of Small Organic Compounds Targeting PDZ Domains;Methods in Molecular Biology;2021

2. Query-guided protein–protein interaction inhibitor discovery;Chemical Science;2021

3. Triazoles in Peptidomimetics: A Recent Update;Advances in Triazole Chemistry;2021

4. Identification of Novel Fragments Binding to the PDZ1‐2 Domain of PSD‐95;ChemMedChem;2020-12-30

5. The electrostatic allostery could be the trigger for the changes in dynamics for the PDZ domain of PICK1;2020-10-06

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