Analogues of the marine alkaloids oroidin, clathrodin, and hymenidin induce apoptosis in human HepG2 and THP-1 cancer cells-Reference-Cited by-同舟云学术

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Analogues of the marine alkaloids oroidin, clathrodin, and hymenidin induce apoptosis in human HepG2 and THP-1 cancer cells

Published:2015 Issue:1 Volume:6 Page:105-110
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Tomašič Tihomir¹²³⁴,Nabergoj Dominik¹²³⁴⁵,Vrbek Sanja¹²³⁴⁵,Zidar Nace¹²³⁴,Jakopin Žiga¹²³⁴,Žula Aleš¹²³⁴,Hodnik Žiga¹²³⁴,Jukič Marko¹²³⁴,Anderluh Marko¹²³⁴,Ilaš Janez¹²³⁴,Dolenc Marija Sollner¹²³⁴,Peluso Jean⁵⁶⁷⁸⁹,Ubeaud-Séquier Geneviève⁵⁶⁷⁸⁹,Muller Christian D.⁵⁶⁷⁸⁹,Mašič Lucija Peterlin¹²³⁴,Kikelj Danijel¹²³⁴

Affiliation:

1. University of Ljubljana

2. Faculty of Pharmacy

3. 1000 Ljubljana

4. Slovenia

5. Laboratoire d'Innovation Thérapeutique

6. UMR 7200

7. Faculté de Pharmacie

8. Université de Strasbourg

9. 67401 Illkirch

Abstract

Structural modification of the marine alkaloid oroidin resulted in improved apoptosis inducing activity in HepG2 and THP-1 cell lines.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C4MD00286E

Reference24 articles.

1. Marine Sponges as Pharmacy

2. Clinical Status of Anti-Cancer Agents Derived from Marine Sources

3. Biosynthesis, asymmetric synthesis, and pharmacology, including cellular targets, of the pyrrole-2-aminoimidazole marine alkaloids

4. 2-Aminoimidazoles in Medicinal Chemistry

5. A Submarine Journey: The Pyrrole-Imidazole Alkaloids

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