Identification of a Novel Structural Class of H<sub>V</sub>1 Inhibitors by Structure-Based Virtual Screening-Reference-Cited by-同舟云学术

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Identification of a Novel Structural Class of H_V1 Inhibitors by Structure-Based Virtual Screening

Published:2024-06-08 Issue:12 Volume:64 Page:4850-4862
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Piga Martina¹^ORCID,Varga Zoltan²,Feher Adam²,Papp Ferenc²,Korpos Eva²³,Bangera Kavya C.²^ORCID,Frlan Rok¹^ORCID,Ilaš Janez¹^ORCID,Dernovšek Jaka¹,Tomašič Tihomir¹^ORCID,Zidar Nace¹^ORCID

Affiliation:

1. Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, Ljubljana 1000, Slovenia

2. Faculty of Medicine, University of Debrecen, Egyetem tér 1, Debrecen H-4032, Hungary

3. HUN-REN−UD Cell Biology and Signaling Research Group, Egyetem tér 1, Debrecen H-4032, Hungary

Funder

Javna Agencija za Raziskovalno Dejavnost RS

Nemzeti Kutat?si Fejleszt?si ?s Innov?ci?s Hivatal

Count Istv?n Tisza Foundation for the University of Debrecen

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.4c00240

Reference45 articles.

1. Role of the Voltage-Gated Proton Channel Hv1 in Nervous Systems

2. A voltage-gated proton-selective channel lacking the pore domain

3. Hydrogen ion currents and intracellular pH in depolarized voltage-clamped snail neurones

4. ATP modulates the activity of the voltage‐gated proton channel through direct binding interaction

5. Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects

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