A highly sensitive fluorescent light-up probe for real-time detection of the endogenous protein target and its antagonism in live cells
Author:
Affiliation:
1. Institute of Materials Research Engineering
2. A*STAR
3. Singapore 117602
4. p53 Laboratory
5. 8A Biomedical Grove
6. Singapore 138648
7. Department of Chemical and Biomolecular Engineering
8. National University of Singapore
9. Singapore 117576
Abstract
A target-specific switchable fluorescent probe for cellular Mdm2 protein detection (off–on) and drug discovery applications (on–off) targeting the p53 pathway.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Materials Science,Biomedical Engineering,General Chemistry,General Medicine
Link
http://pubs.rsc.org/en/content/articlepdf/2015/TB/C5TB00819K
Reference52 articles.
1. p53, guardian of the genome
2. Mdm2 promotes the rapid degradation of p53
3. Regulation of p53 stability by Mdm2
4. DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2
5. On the Interaction Between p53 and MDM2: Transfer NOE Study of a p53-Derived Peptide Ligated to MDM2
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