Understanding the mechanism of action of pyrrolo[3,2-b]quinoxaline-derivatives as kinase inhibitors-Reference-Cited by-同舟云学术

Understanding the mechanism of action of pyrrolo[3,2-b]quinoxaline-derivatives as kinase inhibitors

Published:2020 Issue:6 Volume:11 Page:665-675
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Unzue Andrea¹²³⁴,Jessen-Trefzer Claudia¹²³⁴,Spiliotopoulos Dimitrios⁵²³⁴,Gaudio Eugenio⁶⁷⁸⁴,Tarantelli Chiara⁶⁷⁸⁴,Dong Jing⁵²³⁴,Zhao Hongtao⁵²³⁴,Pachmayr Johanna⁹¹⁰¹¹¹²,Zahler Stefan⁹¹⁰¹¹¹²,Bernasconi Elena⁶⁷⁸⁴,Sartori Giulio⁶⁷⁸⁴,Cascione Luciano⁶⁷⁸⁴¹³^ORCID,Bertoni Francesco⁶⁷⁸⁴¹⁴^ORCID,Śledź Paweł⁵²³⁴,Caflisch Amedeo⁵²³⁴,Nevado Cristina¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Zurich

3. Zürich

4. Switzerland

5. Department of Biochemistry

6. Institute of Oncology Research

7. Faculty of Biomedical Sciences

8. Bellinzona

9. Department of Pharmacy

10. University of Munich

11. 81377 Munich

12. Germany

13. SIB Swiss Institute of Bioinformatics

14. Oncology Institute of Southern Switzerland (IOSI)

Abstract

Two novel quinoxaline-based EphA3 tyrosine kinase inhibitors have been designed and characterized in vivo in a relevant lymphoma model, showing high efficacy in the control of tumor size.

Funder

Krebsliga Schweiz

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/D0MD00049C

Reference42 articles.

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4. Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets

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