Mitochondrial DNA targeting and impairment by a dinuclear Ir–Pt complex that overcomes cisplatin resistance-Reference-Cited by-同舟云学术

Mitochondrial DNA targeting and impairment by a dinuclear Ir–Pt complex that overcomes cisplatin resistance

Published:2020 Issue:9 Volume:7 Page:1864-1871
ISSN:2052-1553
Container-title:Inorganic Chemistry Frontiers
language:en
Short-container-title:Inorg. Chem. Front.

Author:

Zhang Cheng¹²³⁴⁵,Guan Ruilin¹²³⁴⁵,Liao Xinxing¹²³⁴⁵,Ouyang Cheng¹²³⁴⁵,Liu Jiangping¹²³⁴⁵,Ji Liangnian¹²³⁴⁵,Chao Hui¹²³⁴⁵^ORCID

Affiliation:

1. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry

2. School of Chemistry

3. Sun Yat-Sen University

4. Guangzhou

5. P. R. China

Abstract

A dinuclear complex [(ppy)Ir(tpy)PtCl]²⁺ (Ir–Pt) can exhibit strong antitumor activity towards cisplatin-resistant cancer cells and induce cell necrosis via mtDNA damage and mitochondrial dysfunction.

Funder

National Natural Science Foundation of China

Ministry of Education of the People's Republic of China

China Postdoctoral Science Foundation

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/QI/D0QI00224K

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