Topoisomerase IIα poisoning and DNA double-strand breaking by chiral ruthenium(ii) complexes containing 2-furanyl-imidazo[4,5-f][1,10]phenanthroline derivatives-Reference-Cited by-同舟云学术

Topoisomerase IIα poisoning and DNA double-strand breaking by chiral ruthenium(ii) complexes containing 2-furanyl-imidazo[4,5-f][1,10]phenanthroline derivatives

Published:2016 Issue:26 Volume:45 Page:10546-10555
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Qian Chen¹²³⁴⁵,Wu Jingheng¹²³⁴⁵,Ji Liangnian¹²³⁴⁵,Chao Hui¹²³⁴⁵

Affiliation:

1. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry

2. School of Chemistry and Chemical Engineering

3. Sun Yat-Sen University

4. Guangzhou

5. P. R. China

Abstract

Some chiral ruthenium(ii) complexes bearing furan ligands were developed to act as topoisomerase IIα poisons and caused DNA double-strand damage that could lead to apoptosis.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/DT/C6DT01422D

Reference69 articles.

1. DNA TOPOISOMERASES

2. DNA Topoisomerases: Structure, Function, and Mechanism

3. Functional and Regulatory Characteristics of Eukaryotic Type II DNA Topoisomerase

4. New Mechanistic and Functional Insights into DNA Topoisomerases

5. Cellular roles of DNA topoisomerases: a molecular perspective

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