A monoadduct generating Ru(<scp>ii</scp>) complex induces ribosome biogenesis stress and is a molecular mimic of phenanthriplatin-Reference-Cited by-同舟云学术

A monoadduct generating Ru(ii) complex induces ribosome biogenesis stress and is a molecular mimic of phenanthriplatin

Published:2023 Issue:5 Volume:4 Page:344-353
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Mitchell Richard J.¹,Kriger Sarah M.²,Fenton Alexander D.¹,Havrylyuk Dmytro¹,Pandeya Ankit¹,Sun Yang¹,Smith Tami³,DeRouchey Jason E.¹^ORCID,Unrine Jason M.³^ORCID,Oza Viral⁴,Blackburn Jessica S.⁴,Wei Yinan¹^ORCID,Heidary David K.²^ORCID,Glazer Edith C.²^ORCID

Affiliation:

1. Department of Chemistry, University of Kentucky, 505 Rose St., Lexington, KY, 40506, USA

2. Department of Chemistry, North Carolina State University, 2620 Yarbrough DriveRaleigh, NC, 27695, USA

3. Department of Plant and Soil Sciences, University of Kentucky, 1100 S. Limestone St, Lexington, KY, 40546, USA

4. Department of Molecular and Cellular Biochemistry, University of Kentucky, 741 S. Limestone St., Lexington, KY, 40536, USA

Abstract

Phenanthriplatin forms DNA mono-adducts and induces ribosome biogenesis stress. Using a semi-rational strategy, Ru(ii) complexes were created that act as biological mimics of phenanthriplatin with improved properties.

Funder

National Institutes of Health

National Science Foundation

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CB/D2CB00247G

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1. Biochemical Mechanisms of Cisplatin Cytotoxicity