Design, synthesis, and biological evaluation of 3,3′-diindolylmethane <i>N</i>-linked glycoconjugate as a leishmanial topoisomerase IB inhibitor with reduced cytotoxicity-Reference-Cited by-同舟云学术

Design, synthesis, and biological evaluation of 3,3′-diindolylmethane N-linked glycoconjugate as a leishmanial topoisomerase IB inhibitor with reduced cytotoxicity

Published:2023 Issue:10 Volume:14 Page:2100-2114
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Kour Parampreet¹^ORCID,Saha Pallavi²^ORCID,Bhattacharya Srija³^ORCID,Kumari Diksha¹⁴^ORCID,Debnath Abhipsa⁵,Roy Amit⁵,Sharma Deepak K.²^ORCID,Mukherjee Debaraj⁴⁶^ORCID,Singh Kuljit¹⁴^ORCID

Affiliation:

1. Infectious Diseases Division, CSIR – Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India

2. Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology Banaras Hindu University, Varanasi-221005, India

3. Natural Products & Medicinal Chemistry Division, CSIR – Indian Institute of Integrative Medicine, Jammu, 180001, India

4. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India

5. Department of Biotechnology, Savitribai Phule Pune University, Pune-411007, India

6. Department of Chemical Sciences, Unified Academic Campus, Bose Institute, Kolkata, 700091, India

Abstract

Glycosylation of DIM derivatives significantly reduced the cytotoxicity.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00214D

Reference40 articles.

1. A Review of Leishmaniasis: Current Knowledge and Future Directions

2. Leishmaniasis – Authors' reply

3. Exploring the paradox of defense between host and Leishmania parasite

4. Advancement in leishmaniasis diagnosis and therapeutics: An update

5. Current Therapeutics, Their Problems and Thiol Metabolism as Potential Drug Targets in Leishmaniasis

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