Use of ionic liquids in amidation reactions for proteolysis targeting chimera synthesis-Reference-Cited by-同舟云学术

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Use of ionic liquids in amidation reactions for proteolysis targeting chimera synthesis

Published:2024 Issue:17 Volume:22 Page:3477-3489
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Eleuteri Michela¹^ORCID,Desantis Jenny¹^ORCID,Cruciani Gabriele¹,Germani Raimondo¹,Goracci Laura¹^ORCID

Affiliation:

1. Department of Chemistry, Biology, and Biotechnology, University of Perugia, Italy

Abstract

Selective degradation of disease-causing proteins using proteolysis targeting chimeras (PROTACs) has gained great attention, thanks to its several advantages over traditional therapeutic modalities.

Funder

Ministero dell'Università e della Ricerca

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00304G

Reference78 articles.

1. PROTACs: past, present and future

2. PROTAC targeted protein degraders: the past is prologue

3. Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

4. PROTACs: great opportunities for academia and industry

5. A beginner’s guide to current synthetic linker strategies towards VHL-recruiting PROTACs

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