A beginner’s guide to current synthetic linker strategies towards VHL-recruiting PROTACs
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry
Reference120 articles.
1. Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation;Sakamoto;Proc Natl Acad Sci U S A,2001
2. From Discovery to Bedside: Targeting the Ubiquitin System;Wertz;Cell Chem Biol,2019
3. Drug discovery in the ubiquitin-proteasome system;Nalepa;Nat Rev Drug Discov,2006
4. Drugging the undruggables: exploring the ubiquitin system for drug development;Huang;Cell Res,2016
5. Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery;Burslem;Cell,2020
Cited by 18 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. LYMTACs: Chimeric Small Molecules Repurpose Lysosomal Membrane Proteins for Target Protein Relocalization and Degradation;2024-09-10
2. Stereochemical inversion at a 1,4-cyclohexyl PROTAC linker fine-tunes conformation and binding affinity;Bioorganic & Medicinal Chemistry Letters;2024-09
3. Scaffold Hopping of Pristimerin Provides Derivatives Containing a Privileged Quinoxaline Substructure as Potent Autophagy Inducers in Breast Cancer Cells;Journal of Natural Products;2024-08-06
4. Discovery of a Highly Potent, Selective and Efficacious USP7 Degrader for the Treatment of Acute Lymphoblastic Leukemia;Journal of Medicinal Chemistry;2024-07-19
5. Application and challenges of nitrogen heterocycles in PROTAC linker;European Journal of Medicinal Chemistry;2024-07
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3