Fine structural tuning of styryl-based dyes for fluorescence and CD-based sensing of various ds-DNA/RNA sequences

Author:

Botti Valentina1234ORCID,Cesaretti Alessio1234ORCID,Ban Željka5678ORCID,Crnolatac Ivo5678,Consiglio Giuseppe910114,Elisei Fausto1234ORCID,Piantanida Ivo5678

Affiliation:

1. Department of Chemistry

2. Biology and Biotechnology and Centro di Eccellenza sui Materiali Innovativi Nanostrutturati (CEMIN) University of Perugia

3. 06123 Perugia

4. Italy

5. Division of Organic Chemistry & Biochemistry

6. Ruđer Bošković Institute

7. 10002 Zagreb

8. Croatia

9. Department of Chemical Sciences

10. University of Catania

11. 95125 Catania

Abstract

A strong impact of fluorophores’ charge and length on the binding mode, intracellular distribution and antiproliferative activity; intriguing theragnostic potential.

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Università degli Studi di Perugia

Hrvatska Zaklada za Znanost

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference47 articles.

1. R. B. Silverman , The organic chemistry of drug design and drug action , Elsevier Academic Press , Amsterdam , 2nd edn, 2004

2. Fluorescence technologies for the investigation of chemical libraries

3. M. Demeunynck , C.Bailly and W. D.Wilson , Small Molecule DNA and RNA Binders: From Synthesis to Nucleic Acid Complexes , Wiley-VCH Verlag GmbH & Co. KGaA , 2004

4. DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action

5. Intercalators as Anticancer Drugs

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