Development of electrospun, biomimetic tympanic membrane implants with tunable mechanical and oscillatory properties for myringoplasty

Author:

Benecke Lukas1ORCID,Chen Zhaoyu2ORCID,Zeidler-Rentzsch Ines2,von Witzleben Max3,Bornitz Matthias2ORCID,Zahnert Thomas2,Neudert Marcus2ORCID,Cherif Chokri1,Aibibu Dilbar1

Affiliation:

1. Technische Universität Dresden, Faculty of Mechanical Science and Engineering, Institute of Textile Machinery and High Performance Material Technology, Breitscheidstraße 78, 01237 Dresden, Germany

2. Technische Universität Dresden, Carl Gustav Carus Faculty of Medicine, Department of Otorhinolaryngology, Head and Neck Surgery, Ear Research Center Dresden, Fetscherstraße 74, 01307 Dresden, Germany

3. Technische Universität Dresden, Carl Gustav Carus Faculty of Medicine, Center for Translational Bone, Joint and Soft Tissue Research, Fetscherstraße 74, 01307 Dresden, Germany

Abstract

The mechanical and oscillatory behavior of the biomimetic electrospun SF-PCL TM implants can be tuned by adjusting the solution concentration, the SF-PCL mixing ratio and the electrospinning parameters to achieve comparable properties to human TMs.

Funder

Allianz Industrie Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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