Deconvoluting low yield from weak potency in direct-to-biology workflows with machine learning
Author:
Affiliation:
1. Cavendish Laboratory, University of Cambridge, UK
2. Department of Chemical and Structural Biology, The Weizmann Institute of Science, Israel
3. Yusuf Hamied Department of Chemistry, University of Cambridge, UK
Abstract
Funder
Royal Society
Israel Science Foundation
Publisher
Royal Society of Chemistry (RSC)
Link
http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00719G
Reference28 articles.
1. Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation
2. Integrated Direct-to-Biology Platform for the Nanoscale Synthesis and Biological Evaluation of PROTACs
3. A direct-to-biology high-throughput chemistry approach to reactive fragment screening
4. Nanoscale synthesis and affinity ranking
5. Random forest classification for predicting lifespan-extending chemical compounds
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