Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation-Reference-Cited by-同舟云学术

Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation

Published:2022-06-20 Issue:7 Volume:13 Page:1182-1190
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Hendrick Charles E.¹^ORCID,Jorgensen Jeff R.²,Chaudhry Charu²,Strambeanu Iulia I.¹,Brazeau Jean-Francois³,Schiffer Jamie⁴,Shi Zhicai¹,Venable Jennifer D.³,Wolkenberg Scott E.¹^ORCID

Affiliation:

1. Discovery Chemistry, Therapeutics Discovery, Janssen Research & Development, LLC,Welsh & McKean Roads, Spring House, Pennsylvania 19477, United States

2. Discovery Technology and Molecular Pharmacology, Therapeutics Discovery, Janssen Research & Development, LLC, Welsh & McKean Roads, Spring House, Pennsylvania 19477, United States

3. Discovery Chemistry, Therapeutics Discovery, Janssen Research & Development, LLC, 3210 Merryfield Row, La Jolla, California 92121, United States

4. Computational Chemistry, Therapeutics Discovery, Janssen Research & Development, LLC, 3210 Merryfield Row, La Jolla, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00124

Reference36 articles.

1. Development of targeted protein degradation therapeutics

2. Recent Developments in PROTAC‐Mediated Protein Degradation: From Bench to Clinic

3. Small-Molecule Approaches to Targeted Protein Degradation

4. Small-Molecule Modulation of Protein Homeostasis

5. Advancing targeted protein degradation for cancer therapy

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