Ecofriendly aminochalcogenation of alkenes: a green alternative to obtain compounds with potential anti-SARS-CoV-2 activity

Author:

Gomes Luana S.1ORCID,Neto José S. S.2ORCID,di Leo Iris1,Barbosa Cecília G.3,Moraes Carolina B.3,Freitas-Junior Lucio H.3,Rizzuti Bruno45ORCID,Santi Claudio6ORCID,Nascimento Vanessa1ORCID

Affiliation:

1. SupraSelen Laboratory, Department of Chemistry, Federal University Fluminense, Institute of Chemistry, Campus do Valonguinho, Niterói-RJ 24020-141, Brazil

2. Federal University of Santa Catarina, Department of Chemistry, Florianópolis-SC CEP 88040-900, Brazil

3. Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo-SP CEP 05508-900, Brazil

4. CNR-NANOTEC, SS Rende, Department of Physics, University of Calabria, Rende (CS) 87036, Italy

5. Institute of Biocomputation and Physics of Complex Systems, Joint Unit GBsC-CSIC-BIFI, University of Zaragoza, Zaragoza 50018, Spain

6. Dipartimento di Scienze Farmaceutiche, Università di Perugia, Via del Liceo 1, Perugia 06134, Italy

Abstract

We report a solvent- and metal-free methodology for the aminochalcogenation of alkenes, usingI2/DMSO as catalytic system, under microwave irradiation. Some of the obtained compounds showed potent antiviral activity against the coronavirus SARS-CoV-2.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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