Advances in synthesis and anticancer applications of organo-tellurium compounds

Author:

Al-joborae Fadhil Farhood M.1,Al-Rawi Sawsan S.2ORCID,Ibrahim Ahmad H.3ORCID,Salman Abbas Washeel4,Iqbal Muhammad Adnan5ORCID

Affiliation:

1. Department of Intelligent Medical Systems, College of Sciences , Al-Mustaqbal Universty , 51001 , Babylon , Iraq

2. Biology Education Department, Faculty of Education , Tishk International University , 100Mt. St, Near Baz Intersection , Erbil , KRG , Iraq

3. Pharmacy Department, Faculty of Pharmacy , Tishk International University , 100Mt. St, Near Baz Intersection , Erbil , KRG , Iraq

4. Department of Production, College of Agriculture , Wasit University , Kut , Wasit 52001 , Iraq

5. Department of Chemistry , 66724 University of Agriculture Faisalabad , Faisalabad , Pakistan

Abstract

Abstract The present review deeply delves the major methods for the synthesis of organotellurium compounds along with their biological significance. Elaboration of various precursors (ligands) including Schiff bases, naphthoquinones, amino acids, β-hydroxy alkylated compounds, β-phenyltelluro alcohols, β-aryltelluro amines, β-aryl-chalcogenium azides, chalcogenobiotin, benzenesulfonamide, carbonic anhydrase, and Sulpha compounds has been briefly described. Furthermore, the article investigates their possible biological uses, specifically as antioxidant and anticancer agents while comparing their effectiveness with their respective ligands and with the standard medications in terms IC50 values. All types of details are haunted to make the information a priceless resource for researchers who wish to probe deeper into and examine the diverse roles that organotellurium complexes play in biological settings.

Funder

Pakistan Science Foundation

Publisher

Walter de Gruyter GmbH

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