Chemical exchange of labile protons by deuterium enables selective detection of pharmaceuticals in solid formulations-Reference-Cited by-同舟云学术

Chemical exchange of labile protons by deuterium enables selective detection of pharmaceuticals in solid formulations

Published:2022 Issue:82 Volume:58 Page:11551-11554
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Welton Claire¹,Raval Parth¹,Trébosc Julien²,Reddy G. N. Manjunatha¹^ORCID

Affiliation:

1. University of Lille, CNRS, Centrale Lille Institut, Univ. Artois, UMR 8181 – UCCS – Unité de Catalyse et Chimie du Solide, F-59000, Lille, France

2. University of Lille, CNRS, INRAE, Centrale Lille, Univ. Artois, FR 2638 – IMEC – Institut Michel-Eugène Chevreul, F-59000, Lille, France

Abstract

A solid-state 1H–2H isotope correlation NMR spectroscopy (iCOSY) approach is introduced to detect low concentrations of deuterated drugs in pharmaceutical formulations.

Funder

H2020 Marie Skłodowska-Curie Actions

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC04585K

Reference35 articles.

1. Recent Developments for the Deuterium and Tritium Labeling of Organic Molecules

2. Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences

3. Deuterated active pharmaceutical ingredients: A science-based proposal for synthesis, analysis, and control. Part 1: Framing the problem

4. Deuterated Drug Molecules: Focus on FDA-Approved Deutetrabenazine

5. Using Deuterium in Drug Discovery: Leaving the Label in the Drug

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