The design, synthesis and evaluation of low molecular weight acidic sulfonamides as URAT1 inhibitors for the treatment of gout
Author:
Affiliation:
1. Pharmacokinetics Dynamics and Metabolism
2. Pfizer Ltd
3. Cambridge
4. UK
5. Worldwide Medicinal Chemistry
6. Discovery Biology
7. Peakdale Molecular Ltd
8. Sandwich
9. Drug Safety
10. Pharmaceutical Sciences, Research & Development
Abstract
A series of low molecular weight and synthetically facile acidic sulfonamides that are potent and selective URAT1 inhibitors is described.
Publisher
Royal Society of Chemistry (RSC)
Subject
Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/MD/C6MD00191B
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3. Functional Cooperation of SMCTs and URAT1 for Renal Reabsorption Transport of Urate
4. Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate
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