Sustainable chemo-enzymatic preparation of enantiopure (R)-β-hydroxy-1,2,3-triazoles via lactic acid bacteria-mediated bioreduction of aromatic ketones and a heterogeneous “click” cycloaddition reaction in deep eutectic solvents

Author:

Vitale Paola12345ORCID,Lavolpe Francesco12345,Valerio Francesca645ORCID,Di Biase Mariaelena645ORCID,Perna Filippo Maria12345ORCID,Messina Eugenia789510ORCID,Agrimi Gennaro789510ORCID,Pisano Isabella789510ORCID,Capriati Vito12345ORCID

Affiliation:

1. Dipartimento di Farmacia–Scienze del Farmaco

2. Università di Bari “A. Moro”

3. Consorzio C.I.N.M.P.I.S.

4. Bari

5. Italy

6. CNR Institute of Sciences of Food Production (ISPA)

7. Department of Biosciences, Biotechnologies and Biopharmaceutics

8. University of Bari

9. I-70125 Bari

10. CIRCC - Interuniversity Consortium Chemical Reactivity and Catalysis

Abstract

A chemo-enzymatic strategy for the preparation of enantiopure (R)-β-hydroxy-1,2,3-triazoles using a lactic acid bacterium as a whole-cell biocatalyst and a heterogeneous “click” cycloaddition reaction in deep eutectic solvents is disclosed.

Funder

Universita degli Studi di Bari Aldo Moro

Ministero dell’Istruzione, dell’Università e della Ricerca

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

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