Affiliation:
1. Dipartimento di Farmacia—Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, Consorzio Interuniversitario Nazionale “Metodologie e Processi Innovativi di Sintesi” (C.I.N.M.P.I.S.), Via E. Orabona 4, I-70125 Bari, Italy
Abstract
An enhanced, sustainable, and efficient method for synthesizing tacrine, achieving a 98% yield, has been developed by replacing volatile organic compounds with more eco-friendly solvents such as deep eutectic solvent (DESs). The optimized protocol scales easily to 3 g of substrate without yield loss and extends successfully to tacrine derivatives with reduced hepatotoxicity. Particularly notable is the synthesis of novel triazole-based derivatives, yielding 90–95%, by integrating an in situ preparation of aryl azides in DESs with N-propargyl-substituted tacrine derivatives. Quantitative metrics validate the green aspects of the reported drug development processes.
Funder
MUR
Interuniversity Consortium C.I.N.M.P.I.S.
University of Bari Aldo Moro
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