A mitochondria-targeting hetero-binuclear Ir(iii)–Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells-Reference-Cited by-同舟云学术

A mitochondria-targeting hetero-binuclear Ir(iii)–Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells

Published:2018 Issue:49 Volume:54 Page:6268-6271
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Ouyang Cheng¹²³⁴⁵^ORCID,Chen Lei⁶⁷⁸⁹¹⁰,Rees Thomas W.¹²³⁴⁵,Chen Yu¹²³⁴⁵,Liu Jiankang⁶⁷⁸⁹¹⁰,Ji Liangnian¹²³⁴⁵,Long Jiangang⁶⁷⁸⁹¹⁰,Chao Hui¹²³⁴⁵^ORCID

Affiliation:

1. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry

2. School of Chemistry

3. Sun Yat-Sen University

4. Guangzhou

5. P. R. China

6. Center for Mitochondrial Biology and Medicine

7. The Key Laboratory of Biomedical Information Engineering of Ministry of Education

8. School of Life Science and Technology and Frontier Institute of Science and Technology

9. Xi’an Jiaotong University

10. Xi’an 710049

Abstract

A hetero-binuclear Ir(iii)–Pt(ii) complex can selectively accumulate in the mitochondria to induce mitochondrial DNA (mtDNA) damage and evoke cellular events consistent with necrosis in A549R cells.

Funder

National Natural Science Foundation of China

Pearl River S and T Nova Program of Guangzhou

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC02795A

Reference21 articles.

1. The resurgence of platinum-based cancer chemotherapy

2. A Cisplatin-Loaded Immunochemotherapeutic Nanohybrid Bearing Immune Checkpoint Inhibitors for Enhanced Cervical Cancer Therapy

3. Dehydrobruceine B enhances the cisplatin-induced cytotoxicity through regulation of the mitochondrial apoptotic pathway in lung cancer A549 cells

4. Molecular mechanisms of cisplatin resistance

5. Enhancing Tumor-Specific Uptake of the Anticancer Drug Cisplatin with a Copper Chelator

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