Electrochemical 5-<i>exo-dig</i> aza-cyclization of 2-alkynylbenzamides toward 3-hydroxyisoindolinone derivatives-Reference-Cited by-同舟云学术

Electrochemical 5-exo-dig aza-cyclization of 2-alkynylbenzamides toward 3-hydroxyisoindolinone derivatives

Published:2022 Issue:21 Volume:20 Page:4320-4323
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Shi Zhaojiang¹^ORCID,Li Nan¹,Wang Wei-Zhen¹,Lu Hao-Kuan¹,Yuan Yaofeng¹^ORCID,Li Zhen²^ORCID,Ye Ke-Yin¹³^ORCID

Affiliation:

1. Institute of Pharmaceutical Science and Technology, College of Chemistry, Fuzhou University, Fuzhou 350108, China

2. Institute of Molecular Aggregation Science, Tianjin University, Tianjin 300072, China

3. State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen 361005, China

Abstract

An electrochemical N-attacked 5-exo-dig radical cyclization of 2-alkynylbenzamides toward the synthesis of biologically relevant 3-hydroxyisoindolinone derivatives has been developed.

Funder

State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University

Fuzhou University

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00637E

Reference64 articles.

1. Organocatalytic Asymmetric Transformations Involving the Cyclic Imine Moiety in Indole and Isoindole Related Heterocycles

2. Catalytic Asymmetric Synthesis of Isoindolinones

3. Synthesis and stereoselective catalytic transformations of 3-hydroxyisoindolinones

4. Co(III)-Catalyzed [4+1] Annulation of Amides with Allenes via C−H Activation

5. Utility of Ligand Effect in Homogenous Gold Catalysis: Enabling Regiodivergent π-Bond-Activated Cyclization

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