Studies on the synthesis, stability and conformation of 2-sulfonyl-oxetane fragments-Reference-Cited by-同舟云学术

Studies on the synthesis, stability and conformation of 2-sulfonyl-oxetane fragments

Published:2015 Issue:18 Volume:13 Page:5265-5272
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Morgan K. F.¹²³,Hollingsworth I. A.⁴⁵³,Bull J. A.¹²³

Affiliation:

1. Department of Chemistry Imperial College London

2. London SW7 2AZ

3. UK

4. AstraZeneca Mereside

5. Cheshire

Abstract

A library of 2-sulfonyl oxetane fragments has been synthesised and elaborated into lead-like compounds. The oxetane derivatives were stable to acidic and basic conditions and have 3-preferred conformations.

Funder

Engineering and Physical Sciences Research Council

AstraZeneca

Imperial College London

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00549C

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3. Expanding the Azaspiro[3.3]heptane Family: Synthesis of Novel Highly Functionalized Building Blocks

4. Synthesis of Azaspirocycles and their Evaluation in Drug Discovery

5. Cubanes in Medicinal Chemistry: Synthesis of Functionalized Building Blocks

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