Multifunctional, histidine-tagged polymers: antibody conjugation and signal amplification-Reference-Cited by-同舟云学术

Multifunctional, histidine-tagged polymers: antibody conjugation and signal amplification

Published:2020 Issue:89 Volume:56 Page:13856-13859
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Zhang Yichuan¹²³⁴⁵^ORCID,Gambardella Alessia¹²³⁴,Üçüncü Muhammed¹²³⁴⁶^ORCID,Geng Jin¹²³⁴⁵^ORCID,Clavadetscher Jessica¹²³⁴,Bradley Mark¹²³⁴^ORCID,Lilienkampf Annamaria¹²³⁴^ORCID

Affiliation:

1. EaStCHEM School of Chemistry

2. University of Edinburgh

3. Edinburgh

4. UK

5. Shenzhen Institutes of Advanced Technology

6. Department of Analytical Chemistry, Faculty of Pharmacy

Abstract

A polymer scaffold, with multiple reactive centres, was synthesised by RAFT polymerisation and conjugated to the antibody herceptin. A hexahistidine RAFT agent enabled simple purification of polymer–protein conjugates.

Funder

FP7 Ideas: European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC04591H

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