C5-curcuminoid-4-aminoquinoline based molecular hybrids: design, synthesis and mechanistic investigation of anticancer activity

Author:

Kandi Shamseer Kulangara1234,Manohar Sunny1234,Vélez Gerena Christian E.5678,Zayas Beatriz5678,Malhotra Sanjay V.91011128,Rawat Diwan S.1234

Affiliation:

1. Department of Chemistry

2. University of Delhi

3. Delhi-110007

4. India

5. School of Environmental Affairs

6. Universidad Metropolitana

7. San Juan

8. USA

9. Laboratory of Synthetic Chemistry

10. Leidos Biomedical Research Inc.

11. Frederick National Laboratory for Cancer Research

12. Frederick

Abstract

Novel hybrids exhibiting excellent anticancer activity against most of the NCI 60 cell lines through apoptotic pathways are reported herein.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Reference56 articles.

1. WHO (World Health Organization); World Cancer Report, 2008, 1–26

2. Global cancer transitions according to the Human Development Index (2008–2030): a population-based study

3. http://www.medicalnewstoday.com/info/cancer-oncology (accessed May 2013)

4. S. Dhar and S. J.Lippard, in Bioinorganic Medicinal Chemistry, ed. E. Alessio, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2011, pp. 79–95

5. Alkylating agents and cancer therapy

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