Anticancer perspectives of monocarbonyl analogs of curcumin: A decade (2014

Anticancer perspectives of monocarbonyl analogs of curcumin: A decade (2014–2024) review

Published:2024-06-19 Issue:9 Volume:357 Page:
ISSN:0365-6233
Container-title:Archiv der Pharmazie
language:en
Short-container-title:Archiv der Pharmazie

Author:

Nagargoje Amol A.¹²,Deshmukh Tejshri R.¹,Shaikh Mubarak H.¹³,Khedkar Vijay M.⁴,Shingate Bapurao B.¹^ORCID

Affiliation:

1. Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University Chhatrapati Sambhajinagar (Aurangabad) Maharashtra India

2. Department of Chemistry Khopoli Municipal Council College Khopoli Maharashtra India

3. Department of Chemistry Radhabai Kale Mahila Mahavidyalaya Ahmednagar Maharashtra India

4. School of Pharmacy Vishwakarma University Pune Maharashtra India

Abstract

AbstractMonocarbonyl analogs of curcumin (MACs) represent structurally modified versions of curcumin. The existing literature indicates that MACs exhibit enhanced anticancer properties compared with curcumin. Numerous research articles in recent years have emphasized the significance of MACs as effective anticancer agents. This review focuses on the latest advances in the anticancer potential of MACs, from 2014 to 2024, including discussions on their mechanism of action, structure–activity relationship (SAR), and in silico molecular docking studies.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ardp.202400197

Reference118 articles.

1. Curcumin, a Compound from Natural Sources, a True Scientific Challenge – A Review

2. Eliminating the Heart from the Curcumin Molecule: Monocarbonyl Curcumin Mimics (MACs)

3. Curcumin for malaria therapy

4. Antioxidant activities of curcumin, demethoxycurcumin and bisdemethoxycurcumin