Synthesis of spirocyclic dihydropyrazoles from tosylhydrazones and electron-deficient alkenes-Reference-Cited by-同舟云学术

Synthesis of spirocyclic dihydropyrazoles from tosylhydrazones and electron-deficient alkenes

Published:2022 Issue:11 Volume:20 Page:2255-2260
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wootton Timothy L.¹^ORCID,Allwood Daniel M.¹^ORCID

Affiliation:

1. Biomolecular Sciences Research Centre, Sheffield Hallam University, Howard Street, Sheffield, S1 1WB, UK

Abstract

Spirocyclic heterocycles are highly three-dimensional scaffolds with significant utility in medicinal chemistry. This report demonstrates a procedurally simple method for the synthesis of a range of medicinally relevant spirocyclic dihydropyrazoles.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00093H

Reference31 articles.

1. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

2. Escape from Flatland 2: complexity and promiscuity

3. Two‐ and Three‐dimensional Rings in Drugs

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5. The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

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