Graphene-based biosensor for on-chip detection of bio-orthogonally labeled proteins to identify the circulating biomarkers of aging during heterochronic parabiosis
Author:
Affiliation:
1. University of California
2. Berkeley
3. USA
4. Keck Graduate Institute
5. Claremont Colleges
6. Claremont
7. Scripps College
8. Universidad de Navarra
9. San Sebastián
10. Spain
Abstract
Click-A+Chip identifies azido modified proteins with a novel graphene linker that performs copper-free-click chemistry on the chip's surface.
Funder
National Institutes of Health
Publisher
Royal Society of Chemistry (RSC)
Subject
Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering
Link
http://pubs.rsc.org/en/content/articlepdf/2018/LC/C8LC00446C
Reference22 articles.
1. Anti-aging Drugs: From Basic Research to Clinical Practice , ed. A. Vaiserman , R. Soc. Chem. , 2017
2. Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity
3. Rejuvenation of aged progenitor cells by exposure to a young systemic environment
4. Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy
5. A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood
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