Re-engineering a NiFe hydrogenase to increase the H2production bias while maintaining native levels of O2tolerance-Reference-Cited by-同舟云学术

Re-engineering a NiFe hydrogenase to increase the H2production bias while maintaining native levels of O2tolerance

Published:2016 Issue:58 Volume:52 Page:9133-9136
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Flanagan Lindsey A.¹²³⁴,Wright John J.⁵⁶⁷⁴,Roessler Maxie M.⁵⁶⁷⁴,Moir James W.⁸²⁹⁴,Parkin Alison¹²³⁴

Affiliation:

1. Department of Chemistry

2. University of York

3. York

4. UK

5. School of Biological and Chemical Sciences

6. Queen Mary University of London

7. London E1 4NS

8. Department of Biology

9. York YO10 5DD

Abstract

A single site amino acid exchange yields a NiFe hydrogenase with increased bias towards hydrogen production but conserved oxygen tolerance.

Funder

Wellcome Trust

Engineering and Physical Sciences Research Council

Royal Society

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC00515B

Reference21 articles.

1. A. Parkin , in The Metal-Driven Biogeochemistry of Gaseous Compounds in the Environment, ed. P. M. H. Kroneck and M. E. S. Torres, Springer, Netherlands, 2014, vol. 14, p. 99

2. Hydrogenases

3. The hows and whys of aerobic H2 metabolism

4. Structural basis for a [4Fe-3S] cluster in the oxygen-tolerant membrane-bound [NiFe]-hydrogenase

5. Oxygen-Tolerant [NiFe]-Hydrogenases: The Individual and Collective Importance of Supernumerary Cysteines at the Proximal Fe-S Cluster

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