Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1)-Reference-Cited by-同舟云学术

Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1)

Published:2019 Issue:79 Volume:55 Page:11956-11959
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Takahashi Nobuaki¹²³⁴⁵,Hayashi Hideaki¹²³⁴⁵,Poznaks Viktors¹²³⁴⁵,Kakeya Hideaki¹²³⁴⁵^ORCID

Affiliation:

1. Department of System Chemotherapy and Molecular Sciences

2. Division of Bioinformatics and Chemical Genomics

3. Graduate School of Pharmaceutical Sciences, Kyoto University

4. Sakyo-ku

5. Kyoto 606-8501

Abstract

The first total synthesis of vercopeptin (1), an inhibitor of hypoxia-inducible factor 1 (HIF-1), was achieved via condensation of the depsipeptide core and the polyketide side chain unit.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Japan Agency for Medical Research and Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C9CC06169J

Reference22 articles.

1. Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

2. Regulatory mechanisms of hypoxia‐inducible factor 1 activity: Two decades of knowledge

3. Design, synthesis, and structure–activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors

4. Structure Elucidation of Verucopeptin, a HIF-1 Inhibitory Polyketide–Hexapeptide Hybrid Metabolite from an Actinomycete

5. Natural products-prompted chemical biology: phenotypic screening and a new platform for target identification

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