Natural products-prompted chemical biology: phenotypic screening and a new platform for target identification-Reference-Cited by-同舟云学术

Natural products-prompted chemical biology: phenotypic screening and a new platform for target identification

Published:2016 Issue:5 Volume:33 Page:648-654
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Kakeya Hideaki¹²³⁴⁵

Affiliation:

1. Department of System Chemotherapy and Molecular Sciences

2. Division of Bioinformatics and Chemical Genomics

3. Graduate School of Pharmaceutical Sciences

4. Kyoto University

5. Kyoto 606-8501

Abstract

This highlight focuses on our recent discoveries and chemical genetics approaches for bioactive microbial metabolites that target cancer cells, the cancer microenvironment, and cell membrane signalling. In addition, the development of two new platforms to identify the cellular targets of these molecules is also discussed.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/NP/C5NP00120J

Reference44 articles.

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