Regulating the surface topography of CpG nanoadjuvants via coordination-driven self-assembly for enhanced tumor immunotherapy

Author:

Zhang Li123,Zhang Lingpu4,Wang Yuqi5,Jiang Kai5,Gao Chao5,Zhang Pengfei2,Xie Yujie6ORCID,Wang Bin4,Zhao Yun1,Xiao Haihua4ORCID,Song Jie25ORCID

Affiliation:

1. School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, Zhejiang 310024, China

2. Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China

3. School of Pharmacy, Changzhou University, Changzhou, Jiangsu 213164, China

4. Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

5. Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China

6. School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK

Abstract

Novel cytosine–phosphate–guanine (CpG) nanoadjuvants with different surface topographies were constructed for improving adjuvant properties and enhancing tumor immunotherapy.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

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