Kinetics and mechanism of ionic-liquid induced protein unfolding: application to the model protein HP35-Reference-Cited by-同舟云学术

Kinetics and mechanism of ionic-liquid induced protein unfolding: application to the model protein HP35

Published:2016 Issue:4 Volume:1 Page:382-390
ISSN:2058-9689
Container-title:Molecular Systems Design & Engineering
language:en
Short-container-title:Mol. Syst. Des. Eng.

Author:

Tung Hsin-Ju¹²³⁴,Pfaendtner Jim¹²³⁴

Affiliation:

1. Department of Chemical Engineering

2. University of Washington

3. Seattle

4. USA

Abstract

We demonstrate an approach to quantify protein unfolding times using molecular simulation in a greatly accelerated manner compared to standard MD simulations, showing up to 400 fold speed increases.

Funder

Division of Chemical, Bioengineering, Environmental, and Transport Systems

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Industrial and Manufacturing Engineering,Process Chemistry and Technology,Energy Engineering and Power Technology,Biomedical Engineering,Chemical Engineering (miscellaneous),Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2016/ME/C6ME00047A

Reference68 articles.

1. Application of ionic liquids for effective use of woody biomass

2. Effect of ionic liquid on activity, stability, and structure of enzymes: A review

3. Protein solubilising and stabilising ionic liquids

4. How ionic liquids can help to stabilize native proteins

5. Influence of the ionic liquid [C 4 mpy][Tf 2 N] on the structure of the miniprotein Trp-cage

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