Ion-combination specific effects driving the enzymatic activity of halophilic alcohol dehydrogenase 2 from <i>Haloferax volcanii</i> in aqueous ionic liquid solvent mixtures-Reference-Cited by-同舟云学术

Ion-combination specific effects driving the enzymatic activity of halophilic alcohol dehydrogenase 2 from Haloferax volcanii in aqueous ionic liquid solvent mixtures

Published:2024 Issue:9 Volume:2 Page:2559-2580
ISSN:2753-8125
Container-title:RSC Sustainability
language:en
Short-container-title:RSC Sustain.

Author:

Schindl Alexandra¹²³⁴⁵^ORCID,Hagen M. Lawrence¹^ORCID,Cooley Isabel⁶^ORCID,Jäger Christof M.¹⁷^ORCID,Warden Andrew C.⁸⁹^ORCID,Zelzer Mischa²^ORCID,Allers Thorsten³^ORCID,Croft Anna K.⁶^ORCID

Affiliation:

1. Sustainable Process Technologies Group, Department of Chemical and Environmental Engineering, University of Nottingham, Nottingham NG7 2RD, UK

2. School of Pharmacy, University of Nottingham, University Park Campus, Nottingham NG7 2RD, UK

3. School of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK

4. School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK

5. Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK

6. Department of Chemical Engineering, Loughborough University, LE11 3TU, UK

7. Data Science and Modelling, Pharmaceutical Sciences, R&D, AstraZeneca Gothenburg, Pepparedsleden 1, SE-431 83 Mölndal, Sweden

8. CSIRO Environment, Commonwealth Scientific and Industrial Research Organization (CSIRO), Research and Innovation Park, Acton, Canberra, ACT, 2600, Australia

9. Advanced Engineering Biology Future Science Platform, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Research and Innovation Park, Acton, Canberra, ACT, 2600, Australia

Abstract

Cooperative ion–ion interactions drive the selectivity of ion–protein interactions for the halophilic protein ADH in aqueous solutions, with water molecules tightly bound to acidic residues playing an influential role.

Funder

Leverhulme Trust

University of Nottingham

Biotechnology and Biological Sciences Research Council

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SU/D3SU00412K

Reference136 articles.

1. Shortening Synthetic Routes to Small Molecule Active Pharmaceutical Ingredients Employing Biocatalytic Methods

2. Industrial Applications of Enzymes: Recent Advances, Techniques, and Outlooks

3. Green solvents and biocatalysis: A bigger picture

4. Proteins in Ionic Liquids: Reactions, Applications, and Futures

5. Recent advances in the use of ionic liquids as solvents for protein-based materials and chemistry