Long-range PEG stapling: macrocyclization for increased protein conformational stability and resistance to proteolysis-Reference-Cited by-同舟云学术

Long-range PEG stapling: macrocyclization for increased protein conformational stability and resistance to proteolysis

Published:2020 Issue:4 Volume:1 Page:273-280
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Xiao Qiang¹²³⁴,Ashton Dallin S.¹²³⁴,Jones Zachary B.¹²³⁴,Thompson Katherine P.¹²³⁴,Price Joshua L.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry

2. Brigham Young University

3. Provo

4. USA

Abstract

Long-range stapling of two Asn-linked PEG oligomers via olefin metathesis substantially increases the conformational stability of the WW and SH3 domain tertiary structures and the GCN4 coiled-coil quaternary structure.

Funder

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CB/D0CB00075B

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