The Minimum Protein Staple? – Towards ‘bio’-Baldwin's rules <i>via</i> inter-phosphosite linking in the MEK1 activation loop-Reference-Cited by-同舟云学术

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The Minimum Protein Staple? – Towards ‘bio’-Baldwin's rules via inter-phosphosite linking in the MEK1 activation loop

Published:2024 Issue:4 Volume:15 Page:1306-1317
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Galan Sébastien R. G.¹^ORCID,Raj Ritu¹^ORCID,Mamalis Dimitrios¹²,Jones Lyn H.³^ORCID,Mohammed Shabaz¹²^ORCID,Davis Benjamin G.¹²⁴^ORCID

Affiliation:

1. Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK

2. The Rosalind Franklin Institute, Oxfordshire, OX11 0FA, UK

3. Dana–Farber Cancer Institute, Boston, Massachusetts, USA

4. Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK

Abstract

One-out-of-six regioselectivity allows the use of poly-Cys arrays to report on protein structure and reactivity in a biological extension of the Baldwin rules.

Funder

AstraZeneca

Biotechnology and Biological Sciences Research Council

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC04631A

Reference50 articles.

1. Rules for ring closure

2. Ueber die gegenseitige Umwandlung optischer Antipoden

3. Stereochemistry of reaction paths at carbonyl centres

4. The Baldwin rules: revised and extended

5. Stereoelectronic effects in biomolecules

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