An approach to “escape from flatland”: chemo-enzymatic synthesis and biological profiling of a library of bridged bicyclic compounds-Reference-Cited by-同舟云学术

An approach to “escape from flatland”: chemo-enzymatic synthesis and biological profiling of a library of bridged bicyclic compounds

Published:2016 Issue:15 Volume:14 Page:3821-3837
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Suryanarayana Birudukota N. V.¹²³⁴,Franke Raimo¹²³⁴,Hofer Bernd¹²³⁴

Affiliation:

1. Department of Chemical Biology

2. Helmholtz Centre for Infection Research

3. D-38124 Braunschweig

4. Germany

Abstract

A small library of 78 bridged bicyclic compounds were synthesized via a chemo-enzymatic pathway. Biological evaluation suggested that rigid spherical scaffolds are useful to enhance the success rate of compound libraries for drug development.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB02539G

Reference31 articles.

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